A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal response

RA Busuttil; J George; RW Tothill; K Ioculano; A Kowalczyk; C Mitchell; S Lade; P Tan; I Haviv; A Boussioutas

Journal article

A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal response

RA Busuttil, J George, RW Tothill, K Ioculano, A Kowalczyk, C Mitchell, S Lade, P Tan, I Haviv, A Boussioutas

Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2014

DOI: 10.1158/1078-0432.CCR-13-3049

Abstract

Purpose: Gene-expression profiling has revolutionized the way we think about cancer and confers the ability to observe the synchronous expression of thousands of genes. The use of putative genome-level expression profiles has allowed biologists to observe the complex interactions of genes that constitute recognized biologic pathways. We used gastric and ovarian datasets to identify gene-expression signatures and determine any functional significance. Experimental Design: Microarray data of 94-tumor and 45-benign samples derived from patients with gastric cancer were interrogated using Hierarchical Ordered Partitioning and Collapsing Hybrid analysis identifying clusters of coexpressed genes. ..

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University of Melbourne Researchers

Richard Tothill Author

Catherine Mitchell Author

Related Projects (1)

Gastric cancer: Early detection of disease, relapse and prediction of extent of diasease

Gastric cancer (GC) is the second commonest cause of cancer in the world. The mainstay of treatment for GC is surgical resection, but despit..

Grants

Awarded by NHMRC

Funding Acknowledgements

This work was supported by the NHMRC (grant 288714), A. Kowalczyk was financially supported by National ICT Australia (NICTA), which is funded by the Australian Government through the Department of Communications and the Australian Research Council through the ICT Centre of Excellence Program.